Publications

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2009

Portrait of a canine probiotic Bifidobacterium - From gut to gut
D. O'Mahony, K. Barry Murphy, J. MacSharry, T. Boileau, G. Sunvold, G. Reinhart, B. Kiely, F. Shanahan, L. O'Mahony. Vet. Microbiol. (2009).

Metabolic activity of the enteric microbiota influences the fatty acid composition of murine and porcine liver and adipose tissues.
Wall R, Ross RP, Shanahan F, O'Mahony L, O'Mahony C, Coakley M, Hart O, Lawlor P, Quigley EM, Kiely B, Fitzgerald GF, Stanton C.
Am J Clin Nutr. 2009 May;89(5):1393-401.

A Molecular Analysis of Fecal and Mucosal Bacterial Communities in Irritable Bowel Syndrome.
Codling C, O'Mahony L, Shanahan F, Quigley EM, Marchesi JR.
Dig Dis Sci. 2009 Aug 20.

Modulation of pathogen-induced CCL20 secretion from human HT-29 intestinal epithelial cells by commensal bacteria.
Sibartie S, O'Hara AM, Ryan J, Fanning A, O'Mahony J, O'Neill S, Sheil B, O'Mahony L, Shanahan F.
BMC Immunol. 2009 Oct 8;10(1):54.

Clinical Benefits of Probiotic Canine-Derived Bifidobacterium animalis Strain AHC7 in Dogs with Acute Idiopathic Diarrhea.
Kelley RL, Minikhiem D, Kiely B, O’Mahony L, O’Sullivan D, Boileau T, Park JS
Vet Therapeutics 2009;10(3):121-30.

The vexed relationship between Clostridium difficile and inflammatory bowel disease: an assessment of carriage in an outpatient setting among patients in remission.
Clayton EM, Rea MC, Shanahan F, Quigley EM, Kiely B, Hill C, Ross RP.
Am J Gastroenterol. 2009 May;104(5):1162-9.

2008

Metabolic activity of probiotics-Oxalate degradation.
Murphy C, Murphy S, O'Brien F, O'Donoghue M, Boileau T, Sunvold G, Reinhart G, Kiely B, Shanahan F, O'Mahony L. Vet Microbiol. 2008 Oct 15. [Epub ahead of print
PMID: 19028028 [PubMed - as supplied by publisher]

Commensal-Induced Regulatory T Cells Mediate Protection against Pathogen-Stimulated NF-kB Activation
Caitlin O'Mahony, Paul Scully, David O'Mahony, Sharon Murphy, Frances O'Brien, Anne Lyons, Graham Sherlock, John MacSharry, Barry Kiely, Fergus Shanahan, Liam O'Mahony
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
Alimentary Health Ltd., University College Cork, Cork, Ireland.

Mucosal cytokine imbalance in irritable bowel syndrome.
Macsharry J, O'Mahony L, Fanning A, Bairead E, Sherlock G, Tiesman J, Fulmer A, Kiely B, Dinan TG, Shanahan F, Quigley EM.
Scand J Gastroenterol. 2008;43(12):1467-76.

Protective effects of Lactobacillus reuteri and Bifidobacterium infantis in murine models for colitis do not involve the vagus nerve.
van der Kleij H, O'Mahony C, Shanahan F, O'Mahony L, Bienenstock J.
Am J Physiol Regul Integr Comp Physiol. 2008 Oct;295(4):R1131-7.

The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Desbonnet L, Garrett L, Clarke G, Bienenstock J, Dinan TG.
J Psychiatr Res. 2008 Dec;43(2):164-74.

2007

Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118
Sinéad C. Corr*, Yin Li*†, Christian U. Riedel*, Paul W. O'Toole*, Colin Hill*‡, and Cormac G. M. Gahan*§ *Alimentary Pharmabiotic Centre and Department of Microbiology and §School of Pharmacy, University College Cork, Cork, Ireland PNAS 2007.

Probiotic Effects on Inflammatory Bowel Disease
Barbara Sheil, Fergus Shanahan, and Liam O'Mahony* Alimentary Pharmabiotic Centre and Departments of Medicine and Microbiology, University College Cork, Cork, Ireland The Journal of Nutrition 2007.

Antimicrobial activity of lacticin 3147 against clinical Clostridium difficile strains
Mary C. Rea,1,2 Evelyn Clayton,1,2 Paula M. O'Connor,1,2 Fergus Shanahan,2,3 Barry Kiely,4 R. Paul Ross1,2 and Colin Hill 2,5
1Teagasc, Biotechnology Centre, Moorepark Food Research Centre, Moorepark, Fermoy, Cork, Ireland. 2Alimentary Pharmabiotic Centre, University College, Cork, Ireland 3Department of Medicine, University College, Cork, Ireland 4Alimentary Health, Kinsale, Cork, Ireland 5Department of Microbiology, University College, Cork, Ireland. Journal of Medical Microbiology (2007).

Salmonella typhimurium stimulation combined with tumour-derived heat shock proteins induces potent dentritic cell anti-tumour responses in a murine model
D. A. Shilling,*§ M. J. Smith,†§ R. Tyther,‡ D. Sheehan,‡ K. England,‡ E. G. Kavanagh,† H. P. Redmond,† F. Shanahan* and L. O'Mahony* *Alimentary Pharmabiotic Centre, Departments of †Academic Surgery and ‡Biochemistry, National University of Ireland, Cork, Ireland. Clinical and Experimental Immunology 2007.

2006

Multireplicon genome architecture of Lactobacillus salivarius
Multireplicon genome architecture of Lactobacillus salivarius Marcus J. Claesson*†‡, Yin Li*†‡, Sinead Leahy*†, Carlos Canchaya*†, Jan Peter van Pijkeren*†, Ana M. Cerden˜ o-Ta´ rraga§, Julian Parkhill§, Sarah Flynn*, Gerald C. O'Sullivan, J. Kevin Collins*†, Des Higgins , Fergus Shanahan†**, Gerald F. Fitzgerald*†, Douwe van Sinderen*†, and Paul W. O'Toole*†,†† Departments of *Microbiology and **Medicine and †Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; §Pathogen Sequencing Unit, Wellcome Trust Sanger Centre, Cambridge CB10 1SA, United Kingdom; Cork Cancer Research Centre, Mercy University Hospital, Cork, Ireland; and Conway Institute, University College Dublin, Dublin 4, Ireland PNAS 2006.

Heterologous Expression of BetL, a Betaine Uptake System, Enhances the Stress Tolerance of Lactobacillus salivarius UCC118
Vivien M. Sheehan, Roy D. Sleator, Gerald F. Fitzgerald,* and Colin Hill Department of Microbiology and Alimentary Pharmabiotic Centre, University College, Cork, Ireland APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2006.

Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius
Ann M. O'Hara,1 Padraig O'Regan,1Aine Fanning,1 Caitlin O'Mahony,1 John MacSharry,2 Anne Lyons,2 John Bienenstock,3 Liam O'Mahony1 and Fergus Shanahan1. 1 Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland, 2 Alimentary Health Limited, Kinsale, Cork, Ireland, and 3 Department of Pathology and Molecular Medicine, McMaster University, Ontario, Canada. Immunology 2006.

Role of interleukin (IL-10 ) in probiotic-mediated immune modulation: an assessment in wild-type and IL-10 knock-out mice
B. Sheil,* J. MacSharry, L. O'Callaghan, † A. O'Riordan, A. Waters, J. Morgan, † J. K. Collins,* † L. O'Mahony † and F. Shanahan*. *Department of Medicine and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland, and Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. Clinical and Experimental Immunology 2006.

Efficacy of an Encapsulated Probiotic Bifidobacterium infantis 35624 in Women with Irritable Bowel Syndrome
Peter J. Whorwell, M.D., F.R.C.P.,1 Linda Altringer, B.S.,2 Jorge Morel, Ph.D.,2 Yvonne Bond,3 Duane Charbonneau, Ph.D., 2 Liam O'Mahony, Ph.D., 4 Barry Kiely, Ph.D., 5 Fergus Shanahan, M.D., F.R.C.P., F.R.C.P.I., F.A.C.P.,4 and Eamonn M. M. Quigley, M.D., F.R.C.P., F.A.C.P., F.A.C.G., F.R.C.P.I. 4 1 Department of Medicine, University of Manchester, Manchester, UK; 2 The Procter and Gamble Company,Personal Health Care Division, Mason, Ohio; 3 Procter & Gamble, Rusham Park Technical Center, Egham, UK; 4 Alimentary Pharmabiotic Center, University College, Cork, Ireland; and 5 Alimentary Health Ltd, Kinsale, Co. Cork, Ireland. American Journal of Gastroenterology 2006.

Interest heats up in gastrointestinal space
NATURE BIOTECHNOLOGY 2006

Comparative and Functional Analysis of Sortase-Dependent Proteins in the Predicted Secretome of Lactobacillus salivarius UCC118†
Jan-Peter van Pijkeren,1,2 Carlos Canchaya,2 Kieran A. Ryan,1,2 Yin Li,1,2 Marcus J. Claesson,1,2 Barbara Sheil,2 Lothar Steidler,2 Liam O'Mahony,2 Gerald F. Fitzgerald,1,2 Douwe van Sinderen,1,2 and Paul W. O'Toole1,2* Department of Microbiology, University College Cork, Cork, Ireland,1 and Alimentary Pharmabiotic Centre,University College Cork, Cork, Ireland 2. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, June 2006.

2005

Lactobacillus and Bifidobacterium in Irritable Bowel Syndrome: Symptom Responses and Relationship to Cytokine Profiles
LIAM O'MAHONY,* JANE MCCARTHY,* PETER KELLY,* GEORGE HURLEY,‡ FANGYI LUO,‡ KERSANG CHEN,‡ GERALD C. O'SULLIVAN,* BARRY KIELY,*,§ J. KEVIN COLLINS,* FERGUS SHANAHAN,* and EAMONN M. M. QUIGLEY* *Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; ‡Procter & Gamble Company, Mason, Ohio; and §Alimentary Health Ltd, Kinsale, Cork, Ireland. GASTROENTEROLOGY 2005.

Probiotics in the management of irritable bowel syndrome
P&G Health Sciences Institute 2005

Benefits addociated with supplementation with an encapsulated probiotic preparation in subjects with irritable bowel syndrome
Whorwell P J, Altringer L, Morel JG, Bond Y, Quigley E M M, Shanahan F S. Dept of Medicine University of Manchester UK, The Procter & Gamble Company Personal Health Care Technology Division Health Care Research Center Mason OH USA and Alimentary Pharmabiotic Centre University College Cork Ireland. P&G Health Sciences Institute Publication 2005.

Modulation of cytokine profiles in healthy and IBS subjects following supplementation with the unique probiotic strain, Bifidobacterium infantis 35624
Chang K, Fangyi L, Hendrix S, Altringer L, Charbonneau D, Poehner R, Carryl O, Trowbridge M, O'Mahony L, Quigley E M M, Shanahan F S. The Procter & Gamble Company Personal Health Care Technology Division Health Care Research Center Mason OH USA Baby Care Technology Division Cinncinati OH USA and Alimentary Pharmabiotic Centre University College Cork Ireland. P&G Health Sciences Institute Publication 2005.

Modulatory impact of commensal probiotics on intestinal epithelial cell responses to pro-inflammatory stimuli
Shanahan F S , O'Hara A M, Fanning A, O'Mahony C, O'Reagan P, MacSharry J, O'Mahony L. Alimentary Pharmabiotic Centre, University College, Cork, Ireland. P&G Health Sciences Institute Publication 2005.

Effect of probiotic feeding on Salmonella translocation in a mouse model
Quigley E M M, Sommerfield J, MacSharry J, O'Mahony D, O'Mahony L, Kiely B, Shanahan F S. Alimentary Pharmabiotic Centre, BioSciences Institute, University College, Cork, Ireland. P&G Health Sciences Institute Publication 2005.

Correlation of probiotic Lactobacillus salivarius growth phase with its cell wall-associated proteome
Peter Kelly a, Patricia B. Maguire b, Mary Bennett a, Desmond J. Fitzgerald b, Richard J. Edwards b, Bernd Thiede b, Achim Treumann b, J. Kevin Collins a, Gerald C. O'Sullivan a, Fergus Shanahan a,*, Colum Dunne a. a Department of Medicine, Cork Cancer Research Centre and Alimentary Pharmabiotic Centre at the National University of Ireland, Cork, Ireland b Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland FEMS Microbiology Letters (2005).

Alterations in immunological gene expression from colonic biopsies of female IBS patients following probiotic consumption
Bairead E, O’Mahony L, MacSharry J, Scully P, Fanning A, Kiely B, Shanahan F, Quigley E. Alimentary Pharmabiotic Centre, University College Cork Ireland.

Differential cytokine response from dendritic cells to commensal and pathogenic bacteria in different lymphoid compartments in humans
Liam O'Mahony,1 Louise O'Callaghan,1 Jane McCarthy,1 David Shilling,2 Paul Scully,1 Shomik Sibartie,1 Eamon Kavanagh,2 William O. Kirwan,2 Henry Paul Redmond,2 John Kevin Collins,1 and Fergus Shanahan1 1Alimentary Pharmabiotic Centre and 2 Department of Surgery, University College Cork, National University of Ireland, Cork, Ireland. Am J Physiol Gastrointest Liver Physiol 2005.

2004

Is the mucosal route of administration essential for probiotic function? Subcutaneous administration is associated with attenuation of murine colitis and arthritis
B Sheil, J McCarthy, L O'Mahony, F Shanahan, Alimentary Pharmabiotic Centre, Department of Medicine, National University of Ireland, Cork, Ireland M W Bennett, P Ryan, J J Fitzgibbon, Alimentary Pharmabiotic Centre, Departments of Pathology, National University of Ireland, Cork, Ireland B Kiely, Alimentary Pharmabiotic Centre, Department of Microbiology, National University of Ireland, Cork, Ireland J K Collins, Alimentary Pharmabiotic Centre, Departments of Medicine and Microbiology, National University of Ireland, Cork, Ireland. Gut 2004.

2003

Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance
J McCarthy, G C O'Sullivan, F Shanahan, Department of Medicine, University College Cork, National University of Ireland, Cork, Ireland L O'Mahony, L O'Callaghan, B Sheil, B Kiely, J K Collins, Department of Microbiology, University College Cork, National University of Ireland, Cork, Ireland E E Vaughan, N Fitzsimons, Laboratory of Microbiology, Wageningen University, the Netherlands, J Fitzgibbon, Department of Pathology, University College Cork, National University of Ireland, Cork, Ireland. Gut 2003.

2002

Characterization of the genetic locus responsible for the production of ABP-118, a novel bacteriocin produced by the probiotic bacterium Lactobacillus salivarius subsp. salivarius UCC118
Sarah Flynn,1 Douwe van Sinderen,2 Gerardine M. Thornton,2 Helge Holo,3 Ingolf F. Nes3 and J. Kevin Collins2,4 1,2,4 National Food Biotechnology Centre1, Department of Microbiology2, Department of Medicine4, University College Cork, Cork, Ireland. 3 Laboratory of Microbial Gene Technology, Agricultural University of Norway, N-1432 AI s, Norway. Microbiology (2002).

The survival and colonic adhesion of Bifidobacterium infantis in patients with ulcerative colitis
Atte von Wright a,*, Terttu Vilpponen-Salmel a b, Marta Pages Llopisa a, Kevin Collins c, Barry Kiely c, Fergus Shanahan c, Colum Dunne c a Institute of Applied Biotechnology, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland b Harjula Hospital, FIN-70211 Kuopio, Finland c Departments of Microbiology, Medicine and National Food Biotechnology Centre, University College Cork, Western Road, Cork, Ireland International Dairy Journal 12 (2002).

2001

Probiotic impact on microbial fora, infammation and tumour development in IL-10 knockout mice
L. O'MAHONY*† , M. FEENEY*† , S. O'HALLORAN*† , L. MURPHY*† , B. KIELY †, J. FITZGIBBON à, G. LEE à, G. O'SULLIVAN§, F. SHANAHAN± & J. K. COLLINS*± Departments of *Microbiology and ± Medicine, University College Cork, Ireland; † National Food Biotechnology Centre, University College Cork, Ireland; à Department of Histopathology; and § Department of Surgery, Mercy Hospital, Cork, Ireland. Aliment Pharmacol Ther 2001.

In vitro selection criteria for probiotic bacteria of human origin: correlation with in vivo findings
Colum Dunne, Liam O'Mahony, Lisa Murphy, Gerardine Thornton, Darrin Morrissey, Sile O'Halloran, Maria Feeney, Sarah Flynn, Gerald Fitzgerald, Charles Daly, Barry Kiely, Gerald C O'Sullivan, Fergus Shanahan, and J Kevin Collins. Departments of Microbiology, Food Science and Technology, and Medicine and the National Food Biotechnology Center, University College Cork,Cork, Ireland, and the Department of Surgery, Mercy Hospital, Cork, Ireland. Am J Clin Nutr 2001.

2000

Comparative Survival Rates of Human-Derived Probiotic Lactobacillus paracasei and L. salivarius Strains during Heat Treatment and Spray Drying
G. E. GARDINER,1 E. O'SULLIVAN,2 J. KELLY,1 M. A. E. AUTY,1 G. F. FITZGERALD,2 J. K. COLLINS,2 R. P. ROSS,1* AND C. STANTON1 Teagasc, Dairy Products Research Center, Moorepark, Fermoy, County Cork,1 and Department of Microbiology, University College Cork, Cork,2 Ireland APPLIED AND ENVIRONMENTAL MICROBIOLOGY 2000.

1999

Probiotics: from myth to reality. Demonstration of functionality in animal models of disease and in human clinical trials
Colum Dunne1;2, Lisa Murphy1, Sarah Flynn1, Liam O'Mahony1;2, Sile O'Halloran1, Maria Feeney1, Darrin Morrissey1;2, Gerardine Thornton1, Gerald Fitzgerald1;2, Charles Daly1;2, Barry Kiely2, Eamonn M. M. Quigley4, Gerald C. O'Sullivan3, Fergus Shanahan4 & J. Kevin Collins1;4; 1Department of Microbiology, University College, Cork, Ireland; 2National Food Biotechnology Centre, University College, Cork, Ireland; 3Department of Surgery, Mercy Hospital, Cork, Ireland; 4Department of Medicine, University College, Cork, Ireland. Antonie van Leeuwenhoek, 1999.

Probiotics: towards demonstrating efficacy
T. Mattila-Sandholm,a y S. Blum,b J.K. Collins,c R. Crittenden,a W. de Vos,d C. Dunne,c R. Fonde n,e G. Grenov,f E. Isolauri,h B. Kiely,c P. Marteau,i L. Morelli,j A. Ouwehand,g R. Reniero,b M. Saarela,a S. Salminen,g M. Saxelin,k E. Schiffrin,b F. Shanahan,c E. Vaughan d and A. von Wright l. aVTT Biotechnology, P.O. Box 1500, FIN-02044 VTT, Finland. b Nestle Research Center, Nestec Ltd, P.O. Box 44, CH-1000 Lausanne 26, Switzerland. C University College Cork, Departments of Microbiology & Medicine and National Food Biotechnology Centre, Western Road, Cork, Ireland. D Laboratory of Microbiology, Wageningen University, Hesselink van Suchtelenweg 4, NL-6703 CT Wageningen, The Netherlands. E ARLA R&D, Torsgatan 14, S-10546 Stockholm, Sweden. F Chr. Hansen A/S, 10-12 Bùge Alle , DK-2970 Hùrsholm, Denmark. Trends in Food Science & Technology (1999).

1998

The ability of probiotic bacteria to bind to human intestinal mucus
Pirkka V. Kirjavainen a;*, Arthur C. Ouwehand a, Erika Isolauri b, Seppo J. Salminen a a Department of Biochemistry and Food Chemistry, University of Turku, Fin-20014 Turku, Finland b Department of Paediatrics, Turku University Hospital, Fin-20520 Turku, Finland. FEMS Microbiology Letters (1998).